233 / 658
7
Table 5. Interday repeatability and accuracy for QC1 and QC2
QC 1
QC 2
Compound
Specified
Concentration
Measured
Concentration %RSD
%Accuracy
Specified
Concentration
Measured
Concentration %RSD %Accuracy
7-Aminoclonazepam
16.0
16.7
6.3
104
52.4
53.9
5.3
103
7-Aminoflunitrazepam
16.6
17.4
6.6
105
54.5
53.2
6.5
98
7-Aminonitrazepam
66.4
70.7
5.8
107
221
224
6.1
101
α
-OH-Alprazolam
16.7
17.8
7.4
107
57.0
56.8
5.7
100
α
-OH-Midazolam
64.6
68.0
9.2
105
203
212
8.0
104
α
-OH-Triazolam
13.6
13.4
6.3
98
43.3
43.5
5.3
100
Alprazolam
15.4
16.0
10.3
104
55.5
52.5
6.9
95
Bromazepam
94.3
91.9
12.9
97
296
310
7.9
105
Chlordiazepoxide
621
607
8.8
98
2040
2090
8.2
103
Clobazam
143
146
6.8
102
491
473
5.9
96
Clonazepam
14.6
15.0
5.6
103
49.7
52.7
5.9
106
Demoxepam
682
711
7.5
104
2270
2280
4.3
100
Desalkylflurazepam
31.4
29.5
10.1
94
102
102
7.3
100
Desmethylflunitrazepam
15.2
15.3
7.3
101
51.1
51.8
6.3
101
Diazepam
292
309
8.8
106
949
945
9.5
100
Estazolam
132
129
3.7
98
441
437
7.1
99
Flunitrazepam
15.9
17.4
9.5
109
53.5
52.6
8.7
98
Flurazepam
25.9
27.3
13.4
106
86.2
89.5
8.1
104
Lorazepam
62.1
66.0
6.1
106
205
200
5.7
97
Lormetazepam
5.46
6.00
11.0
111
18.2
18.8
8.8
103
Medazepam
127
131
6.9
103
426
437
12.5
102
Midazolam
93.5
89.0
4.4
95
308
307
4.3
100
Nitrazepam
62.6
69.3
6.9
111
206
203
6.7
99
Norclobazam
835
835
6.3
100
2670
2640
5.6
99
Nordiazepam
239
262
11.6
110
821
802
8.1
98
Oxazepam
377
387
9.3
103
1240
1250
6.5
101
Prazepam
262
265
3.7
101
843
845
4.1
100
Temazepam
128
134
5.8
105
409
437
6.2
107
Tetrazepam
123
127
4.4
103
409
416
7.5
102
Trazodone
516
501
6.6
97
1630
1750
11.6
107
Triazolam
12.1
11.7
6.1
97
40.2
39.7
6.8
99
Zaleplone
26.8
27.1
9.8
101
88.6
85.2
11.2
96
Zolpidem
139
130
7.8
93
468
450
8.0
96