232 / 658
6
Table 4. Intraday repeatability and accuracy for QC1 and QC2
QC 1
QC 2
Compound
Specified
Concentration
Measured
Concentration %RSD
%Accuracy
Specified
Concentration
Measured
Concentration %RSD %Accuracy
7-Aminoclonazepam
16.0
15.5
3.8
97
52.4
54.6
5.2
104
7-Aminoflunitrazepam
16.6
16.8
8.6
101
54.5
55.9
3.0
103
7-Aminonitrazepam
66.4
68.5
3.9
103
221
237
5.1
107
α
-OH-Alprazolam
16.7
17.4
7.1
104
57
59.4
3.9
104
α
-OH-Midazolam
64.6
65.4
3.8
101
203
217
4.1
107
α
-OH-Triazolam
13.6
13.7
8.8
101
43.3
45.7
2.9
105
Alprazolam
15.4
15.7
9.2
102
55.5
55.2
5.8
99
Bromazepam
94.3
97.0
6.9
103
296
320
2.3
108
Chlordiazepoxide
621
602
3.1
97
2040
2150
3.3
105
Clobazam
143
144
7.7
101
491
489
4.4
100
Clonazepam
14.6
14.6
5.2
100
49.7
54.7
7.5
110
Demoxepam
682
673
5.5
99
2270
2350
4.4
103
Desalkylflurazepam
31.4
29.3
9.6
94
102
107
5.0
94
Desmethylflunitrazepam
15.2
14.4
4.6
95
51.1
54.2
3.8
106
Diazepam
292
297
3.4
102
949
941
5.2
99
Estazolam
132
127
2.4
96
441
447
6.6
101
Flunitrazepam
15.9
16.8
12.1
106
53.5
54.7
8.2
102
Flurazepam
25.9
26.9
5.4
104
86.2
93.0
4.7
108
Lorazepam
62.1
67.3
5.6
108
205
210
4.2
103
Lormetazepam
5.46
5.70
9.0
104
18.2
18.9
9.3
104
Medazepam
127
126
5.1
99
426
437
6.1
102
Midazolam
93.5
91.1
4.7
97
308
316
4.1
103
Nitrazepam
62.6
66.5
4.6
106
206
215
3.0
104
Norclobazam
835
811
3.2
97
2670
2770
3.8
104
Nordiazepam
239
245
4.2
103
821
804
4.3
98
Oxazepam
377
383
7.6
101
1240
1240
6.9
100
Prazepam
262
256
1.7
98
843
862
1.6
102
Temazepam
128
135
3.7
105
409
459
1.8
112
Tetrazepam
123
124
1.1
101
409
422
1.6
103
Trazodone
516
503
4.3
98
1630
1810
9.0
111
Triazolam
12.1
11.6
8.4
96
40.2
40.0
11.1
100
Zaleplone
26.8
27.3
8.5
102
88.6
94.1
5.6
106
Zolpidem
139
131
2.3
94
468
463
3.4
99