AI-64310-CRFT

34 / 658

Thermo Fisher Scientific,
San Jose, CA USA is
ISO 9001:2008 Certified.
AN63643_E 01/13S
Africa-Other +27 11 570 1840
Australia +61 3 9757 4300
Austria +43 1 333 50 34 0
Belgium +32 53 73 42 41
Canada +1 800 530 8447
China +86 10 8419 3588
Denmark +45 70 23 62 60
Europe-Other +43 1 333 50 34 0
Finland/Norway/Sweden
+46 8 556 468 00
France +33 1 60 92 48 00
Germany +49 6103 408 1014
India +91 22 6742 9434
Italy +39 02 950 591
Japan +81 45 453 9100
Latin America +1 561 688 8700
Middle East +43 1 333 50 34 0
Netherlands +31 76 579 55 55
New Zealand +64 9 980 6700
Russia/CIS +43 1 333 50 34 0
South Africa +27 11 570 1840
Spain +34 914 845 965
Switzerland +41 61 716 77 00
UK +44 1442 233555
USA +1 800 532 4752
©2013 Thermo Fisher Scientific Inc. All rights reserved. ISO is a trademark of the International Standards Organization
(Organisation Internationale De Normalization). CTC PAL is a registered trademark of Leap Technologies. All other trademarks are
the property of Thermo Fisher Scientific Inc. and its subsidiaries. This information is presented as an example of the capabilities of
Thermo Fisher Scientific Inc. products. It is not intended to encourage use of these products in any manners that might infringe the
intellectual property rights of others. Specifications, terms and pricing are subject to change. Not all products are available in all
countries. Please consult your local sales representative for details.
References
1. Brown, R.C.; Aston, J.P.; St. John, A.; Woodhead, J.S.
Comparison of poly- and monoclonal antibodies as labels in a
two-site immunochemiluminometric assay for intact
parathyroid hormone J. Immunol. Meth. 1988, 109, 139–144.
2. Gao, P.; D’Amour, P. Evolution of the parathyroid hormone
(PTH) assay: importance of circulating PTH
immunoheterogeneity and of its regulation Clin. Lab. 2005, 51,
21–29.
3. Borges, C.R.; Rehder, D.S.; Jarvis, J.W. Schaab, M.R.; Oran,
P.E.; Nelson, R.W. Full-length characterization of proteins in
human populations Clin Chem 2010, 56, 202–211.
4. Langub, M.C.; Monier-Faugere, M.C.; Wang, G.; Williams,
J.P.; Koszewski, N.J.; Malluche, H.H. Administration of
PTH-(7– 84) antagonizes the effects of PTH-(1– 84) on bone in
rats with moderate renal failure Endocrinology 2003, 144,
1135–1138.
5. D’Amour, P. Circulating PTHmolecular forms: what we know
and what we don’t Kidney Int. Suppl.2006, S29–33.
6. John, M.R.; Goodman, W.G.; Gao, P. Cantor, T.L.; Salusky,
I.B.; Juppner, H. A novel immunoradiometric assay detects
full-length human PTH but not amino-terminally truncated
fragments: implications for PTHmeasurements in renal failure
J. Clin. Endocrinol. Metab. 1999, 84, 4287–4290.
7. Salusky, I.B.; Goodman, W.G. Adynamic renal osteodystrophy:
is there a problem? J. Am. Soc. Nephrol. 2001, 12, 1978–1985.
8. Anderson, N.L.; Anderson, N.G.; Haines, L.R.; Hardie, D.B.;
Olafson, R.W.; Pearson, T.W. Mass spectrometric quantitation
of peptides and proteins using stable isotope standards and
capture by anti-peptide antibodies (SISCAPA) J. Proteome Res.,
2004, 3, 235–244.
9. Berna, M.; Schmalz, C.; Duffin, K.; Mitchell, P.; Chambers, M.;
Ackermann, B. Online immunoaffinity liquid chromatography/
tandemmass spectrometry determination of a type II collagen
peptide biomarker in rat urine: Investigation of the impact of
collision-induced dissociation fluctuation on peptide
quantitation Anal. Biochem. 2006, 356, 235–243.
10. Ackermann, B.L.; Berna, M.J. Coupling immunoaffinity
techniques withMS for quantitative analysis of low-abundance
protein biomarkers Expert Rev. Proteomics 2007, 4, 175–186.
11. Berna, M.; Ackermann, B. Increased throughput for low-
abundance protein biomarker verification by liquid
chromatography/tandemmass spectrometry Anal. Chem.
2009, 81, 3950–3956.
12. Lopez, M.F.; Kuppusamy, R.; Sarracino, D.A.; Prakash, A.;
Athanas, M.; Krastins, B. et al. Discovery and targeted SRM
assay development of first trimester peptide biomarker
candidates for trisomy 21 in maternal blood. J. Proteome Res.
2011, 10 (1), 133–142.
13. Nelson, R.W.; Krone, J.R.; Bieber, A.L.; Williams, P. Mass
spectrometric immunoassay Anal. Chem. 1995, 67,
1153–1158.
14. Kiernan, U.A.; Nedelkov, D.; Tubbs, K.A.; Niederkofler, E.E.;
Nelson, R.W. Selected expression profiling of full-length
proteins and their variants in human plasma Clin. Proteomics J.
2004, 1, 7–16.
15. Kiernan, U.A.; Tubbs, K.A.; Nedelkov, D.; Niederkofler, E.E.;
Nelson, R.W. Detection of novel truncated forms of human
serum amyloid A protein in human plasma FEBS Lett, 2003,
537, 166–170.
16. Nedelkov, D.; Kiernan, U.A.; Niederkofler, E.E.; Tubbs, K.A.;
Nelson, R.W. Investigating diversity in human plasma proteins
Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 10852–10857.
17. Nedelkov, D.; Phillips, D.A.; Tubbs, K.A.; Nelson, R.W.
Investigation of human protein variants and their frequency in
the general population, Mol. Cell Proteomics 2007, 6,
1183–1187.
For Research Use Only. Not for use in diagnostic procedures.
Application Note
MSIA1004