136 / 658
Conclusion
TurboFlow technology is a powerful technique for the
direct analysis of drugs in biological fluids without the
need for an extensive number of sample preparation steps.
In this study, the use of an Aria TLX-1 LC system in front
of a TSQ Quantum Ultra allows for low levels of detection
(6.25 ng/mL for C-Dopa; 25 ng/mL for L-Dopa and 3-OMD)
of each of these neurotransmitter compounds in human
whole blood extract and yields results in less than 10 minutes
per sample. With the Aria TLX-4 multiplexed system, the
results will be available about every 2.5 minutes using
only one mass spectrometer. The low variability of the
results demonstrates the reliability of this research
method.
Reference
1. Guidance for Industry Bioanalytical Method Validation, Food and Drug
Administration, May 2001.
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