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Figure 7: Clozapine/Norclozapine reproducibility and variance
Figure 6: Norclozapine calibration curve, 0.05 – 2 mg/L
References
1. Rostami-Hodjegan A, Amin AM, Spencer EP,
Lennard MS, Tucker GT, Flanagan RJ,
J Clin Psychopharmacol 2004; 24 (1): 1-9
2. Flanagan RJ, CPD Clin Biochem 2006; 7 (1): 3-18
Norclozapine
Specified Calculated
Concentration Response Conc Conc % CV
0.05 mg/L 905801 0.05 0.04 0.4
0.05 mg/L 897792 0.05 0.04 0.4
0.05 mg/L 900825 0.05 0.04 0.4
0.10 mg/L 1555897 0.10 0.10 1.1
0.10 mg/L 1554377 0.10 0.10 1.1
0.10 mg/L 1525338 0.10 0.10 1.1
0.20 mg/L 2847998 0.20 0.21 3.1
0.20 mg/L 2859029 0.20 0.21 3.1
0.20 mg/L 3006773 0.20 0.22 3.1
0.50 mg/L 7099512 0.50 0.57 5.0
0.50 mg/L 6741516 0.50 0.54 5.0
0.50 mg/L 6420812 0.50 0.51 5.0
1.00 mg/L 12521697 1.00 1.04 3.6
1.00 mg/L 12383684 1.00 1.02 3.6
1.00 mg/L 11695815 1.00 0.97 3.6
2.00 mg/L 23888229 2.00 2.01 3.5
2.00 mg/L 22259134 2.00 1.87 3.5
2.00 mg/L 23241437 2.00 1.95 3.5
Clozapine
Specified Calculated
Concentration Response Conc Conc % CV
0.05 mg/L 784733 0.05 0.03 1.2
0.05 mg/L 797712 0.05 0.03 1.2
0.05 mg/L 780137 0.05 0.03 1.2
0.10 mg/L 1415271 0.10 0.08 1.7
0.10 mg/L 1456027 0.10 0.09 1.7
0.10 mg/L 1411624 0.10 0.08 1.7
0.20 mg/L 2745962 0.20 0.20 1.8
0.20 mg/L 2743289 0.20 0.20 1.8
0.20 mg/L 2832044 0.20 0.20 1.8
0.50 mg/L 6889405 0.50 0.55 2.6
0.50 mg/L 6682781 0.50 0.54 2.6
0.50 mg/L 6549395 0.50 0.52 2.6
1.00 mg/L 12624439 1.00 1.05 2.3
1.00 mg/L 12261014 1.00 1.02 2.3
1.00 mg/L 12054848 1.00 1.00 2.3
2.00 mg/L 24055429 2.00 2.03 2.5
2.00 mg/L 22868295 2.00 1.93 2.5
2.00 mg/L 23457123 2.00 1.98 2.5