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3

26 ng /mL

ng/mL % Diff

26

10.9

53

-8.5

106

-0.9

212

-4.3

425

2.6

850

0.1

Figure 2. Cyclosporin A

1.3 ng/mL

ng/mL % Diff

1.3

1.7

2.5

-3.8

5.0

5.8

10

-2.5

20

-3.2

40

1.7

Figure 3. Tacrolimus

1.5 ng/mL

ng/mL % Diff

1.5

0.4

3

17.3

6

-16.6

12

2.5

24

-7.9

48

4.3

Figure 4. Sirolimus

RT:

0.58 -1.11

0.6 0.7 0.8 0.9 1.0 1.1

Time (min)

0

5

10

15

20

25

30

35

40

45

50

55

60

65

70

75

80

85

90

95

100

RelativeAbundance

RT:0.82

NL:3.31E3

TICF:+ cESISRM

ms21220.00

[1202.80] MS ICIS

SCH_Immunosuppres

ants_STD_level1_001

RT:

0.56 -1.02

0.6

0.7

0.8

0.9

1.0

Time (min)

0

5

10

15

20

25

30

35

40

45

50

55

60

65

70

75

80

85

90

95

100

RelativeAbundance

RT:0.79

NL:2.30E2

TICF:+ cESISRM

ms2821.60 [768.45]

MS ICIS

SCH_Immunosuppres

ants_STD_level1_001

RT:

0.58 -0.98

0.6

0.7

0.8

0.9

Time (min)

0

5

10

15

20

25

30

35

40

45

50

55

60

65

70

75

80

85

90

95

100

RelativeAbundance

RT:0.80

NL:2.69E1

TICF:+ cESISRM

ms2931.85 [864.50]

MS ICIS

SCH_Immunosuppres

ants_STD_level1_001