Differentiate Minor Difference of Protein
Structure in Biosimilar and Reference Products
Using High-Resolution Orbitrap LC-MS/MS
Zhiqi Hao,
1
David M. Horn,
1
Shiaw-Lin Wu,
2
Fan Zhang,
2
and Patrick Bennett
1
1
Thermo Fisher Scientific, San Jose, CA;
2
Barnett Institute, Northeastern University, Boston, MA