| Cover | 1 |
| Table of Contents | 3 |
| Native and Intact Protein Characterization | 4 |
| Application Notes | 5 |
| Poster Notes | 25 |
| Analysis of Monoclonal Antibodies, Aggregates, and Their Fragments by Size Exclusion Chromatography Coupled with an Orbitrap Mass Spectrometer | 25 |
| Highly Sensitive, Robust MS-Based Workflow for Therapeutic Monoclonal Antibody Analysis from Complex Matrices | 33 |
| Monoclonal Antibody and Related Product Characterization under Native Condition susing a Benchtop Exactive Plus EMR MS | 41 |
| Structure Characterization of Intact Monoclonal Antibody Using an Orbitrap Tribrid Mass Spectrometer | 49 |
| Analysis of Intact Macromolecular Assemblies On A Bench Top Orbitrap MS System | 57 |
| Intact Mass Analysis of Monoclonal Antibody (MAb) Charge Variants Separated Using Linear pH Gradient | 67 |
| Automated MAb Workflow: from Harvest Cell Culture to Intact Mass Analysis of Variants | 75 |
| A High Resolution Bench-Top Orbitrap LC-MS Workflow Solution for Comprehensive Intact Monoclonal Antibody Characterization | 83 |
| Top-Down Analysis of Intact Antibodies Using Orbitrap Mass Spectrometry | 91 |
| Peer Review Journal Articles | 99 |
| Glycan and Glycopeptide Analysis | 100 |
| Application Notes | 101 |
| Poster Notes | 119 |
| Structure Characterization and Differentiation of Biosimilar and Reference Products Using Unique Combination of Complementary Fragmentation Mechanisms | 119 |
| Middle-down Analysis of Monoclonal Antibody Middle using Nano-flow Liquid Chromatography and a Novel Tribrid Orbitrap Mass Spectrometer | 127 |
| Novel Glycan Column Technology for the LC-MS Analysis of Labeled and Native N-Glycans Released from Proteins and Antibodies | 135 |
| Targeted Quantification of O-Linked Glycosylation Site for Glycan Distribution Analysis | 143 |
| A Complete Workflow Solution for Monoclonal Antibody Glycoform Characterization Combining a Novel Glycan Column Technology and Bench-Top Orbitrap LC-MS/MS | 151 |
| Improving Intact Antibody Characterization by Orbitrap Mass Spectrometry | 159 |
| Peer Review Journal Articles | 165 |
| Peptide Mapping and Analysis | 166 |
| Application Notes | 167 |
| Poster Notes | 177 |
| Comprehensive Sequence and Post-translational Modifications Analysis of Monoclonal Antibody by Flash Digest and LC-High Resolution MS | 177 |
| Degradation Profiling of a Monoclonal Antibody Using Multiple Fragmentation Techniques and a Novel Peptide Mapping Software | 185 |
| Disulfide Bond Analysis on Orbitrap Mass Spectrometry | 193 |
| Rapid Peptide Mapping via Automated Integration of On-line Digestion, Separation and Mass Spectrometry for the Analysis of Therapeutic Proteins | 201 |
| Differentiate Minor Difference of Protein Structure in Biosimilar and Reference Products Using High-Resolution Orbitrap LC-MS/MS | 209 |
| Sheathless Capillary Electrophoresis Mass Spectrometry (CESI-MS) as a Versatile and Powerful Tool for the Characterization of Monoclonal Antibodies | 217 |