Biopharmaceutical Characterization Application Compendium - page 99

Native and Intact Protein Characterization
Peer Review Journal Articles:
Rosati, S.; van den Bremer, E.; Schuurman, J.; Parren, P.; Kamerling, J.; Heck, A. J. R. In-depth
qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity
on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap.
mAbs 2013 , 5 (6), 917-924. [Full Text]
Rosati, S.; Thompson, N. J.; Heck, A. J. R. Tackling the increasing complexity of therapeutic monoclonal
antibodies with mass spectrometry. TrAC Trends in Analytical Chemistry 2013, 48, 72-80. [Abstract]
Michalski, A.; Damoc, E.; Lange, O.; Denisov, E.; Nolting, D.; Müller, M.; Viner, R.; Schwartz, J.; Remes,
P.; Belford, M.; Dunyach, J.-J.; Cox, J.; Horning, S.; Mann, M.; Makarov, A. Ultra High Resolution Linear
Ion Trap Orbitrap Mass Spectrometer (Orbitrap Elite) Facilitates Top Down LC MS/MS and Versatile
Peptide Fragmentation Modes. Mol. Cell. Proteomics 2012 , 11 (3). [Full Text]
Mazur, M.; Seipert, R.; Mahon, D.; Zhou, Q.; Liu, T. A Platform for Characterizing Therapeutic Monoclonal
Antibody Breakdown Products by 2D Chromatography and Top-Down Mass Spectrometry . AAPS J .
2012, DOI:10.1208/s12248-012-9361-6. [Full Text]
Fornelli, L.; Damoc, E.; Thomas, P.; Kelleher, N.; Aizikov, K.; Denisov, E.; Makarov, A.; Tsybin, Y.
Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS. Mol. Cell.
Proteomics 2012, 11 (12), 1758-1767. [Full Text]