255 / 658
0.0
20.0
40.0
60.0
80.0
100.0
120.0
140.0
160.0
180.0
200.0
Clonazepam
Clozapine
Lamotrigine
Perhexilline
Levetiracetam
Amitriptyline
Clomipramine
Dothiepin
Doxepin
Imipramine
Nortriptyline
Trimipramine
Bromazepam
Clobazam
Diazepam
Flunitrazepam
Nitrazepam
Oxazepam
Temazepam
200X 80X 40X
0.0
20.0
40.0
60.0
80.0
100.0
120.0
200X 80X 40X
5
Figure 1. Mean signal recovery of 19 drugs at 40 ng/mL in 9 human plasma samples diluted 40-fold, 80-fold, and
200-fold, as compared to a similarly spiked solvent blank
Figure 2. Mean signal recovery of 15 internal standards at 100 ng/mL in 9 human plasma samples diluted 40-fold,
80-fold, and 200-fold, as compared to a similarly spiked solvent blank