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BioPharma 2013_PN63946_E_11/13S
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528.1914
Conclusions
A CESI prototype was coupled to a Q Exactive mass spectrometer for the
characterization of two monoclonal antibodies at the peptide level.
•
CESI-MS was capable of analyzing very small (< 300 Da) and very large peptides
(>8000 Da) under same experimental conditions
100% sequence coverage achieved for each molecule with 1 single run &
1 enzymatic digest
•
High ionization efficiencies provided by CESI and highly sensitive MS
Allowed for in-depth analysis of glycosylations with relative abundance
varying more than 3 orders of magnitude
For Research Use Only. Not for use in diagnostic procedures.
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This information is not intended to encourage use of these products in any manners that might infringe the
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