322 / 658
References
1
Kronstrand, R.; Nystrom, I.; Strandberg, J.; Druid, H. “Screening for drugs
of abuse in hair with ion spray LC-MS-MS”;
Forensic Sci. Int.
2004
,
145
(2-3), 183-190.
2
Allen, K.R.; Azad, R.; Field, H.P.; Blake, D.K. “Replacement of immunoas-
say by LC tandem mass spectrometry for the routine measurement of drugs
of abuse in oral fluid”;
Ann. Clin. Biochem.
2005
,
42
(4), 277-284.
3
Maralikova, B.; Weinmann, W. “Confirmatory analysis for drugs of abuse
in plasma and urine by high-performance liquid chromatography-tandem
mass spectrometry with respect to criteria for compound identification”;
J. Chromatogr. B.
2004
,
811
(1), 21-30.
4
Nordgren, H.K.; Beck, O. “Multicomponent screening for drugs of abuse:
direct analysis of urine by LC-MS-MS”;
Ther. Drug Monit.
2004
,
26
(1),
90-97.
5
Edinboro, L.E.; Backer, R.C.; Poklis, A. “Direct analysis of opiates in urine
by liquid chromatography-tandem mass spectrometry”;
J Anal Toxicol.
2005
,
29
(7), 704-710.
View additional Thermo Scientific LC/MS application notes at:
www.thermo.com/appnotesAN62405_E 11/09S
Part of Thermo Fisher Scientific
:TR
00.6 - 00.1
:MS
G5
1
2
3
4
5
6
)nim( emiT
05
001
05
001
05
001
05
001
05
001
RelativeAbundance
05
001
05
001
05
001
22.2 :TR
3697041 :AA
22.2 :TR
80218705 :AA
22.2 :TR
27400474 :AA
16.3 :TR
3914683 :AA
16.3 :TR
268874 :AA
50.3
48.1
16.3 :TR
145144 :AA
40.3
94.4 :TR
82820608 :AA
84.4 :TR
10967671 :AA
enihproM
Lm/gn 687 = .cnoC .claC
enihproM-3D
)reifilauq( enihproM
%3.39 = oitaR
eniedoC-3D
eniedoC
Lm/gn 39.2 = .cnoC .claC
)reifilauq( eniedoC
%2.29 = oitaR
eninogcelyozneB
Lm/gn 351 = .cnoC .tsE
)reifilauq(eninogcelyozneB
%9.12 = oitaR
Figure 4A: Assay of urine extract (#423) targeting morphine and its
metabolites. The concentration of benzoylecgonine is estimated because
a labeled internal standard was not added to the sample extract.
:TR
00.8 - 00.2
:MS
G7
2
3
4
5
6
7
8
)nim( emiT
05
001
05
001
05
001
05
001
05
001
RelativeAbundance
05
001
05
001
05
001
90.3 :TR
34235074 :AA
90.3 :TR
78410364 :AA
70.4 :TR
49894114 :AA
80.4 :TR
0111412 :AA
80.4 :TR
2297361 :AA
84.4 :TR
377671 :AA
06.6 :TR
798457 :AA
06.6 :TR
25576 :AA
enimatehpmahteM-5D
eninogcelyozneB
eniacoC
Lm/gn 22.0 = .cnoC .tsE
%9.8 = oitaR
)reifilauq( eniacoC
enirdehpE
Lm/gn 902 = .cnoC .tsE
)reifilauq( enirdehpE
enimatehpmahteM
)reifilauq( enimatehpmahteM
Lm/gn 33.1 = .cnoC .claC
%5.67 = oitaR
%4.89 = oitaR
Lm/gn 91.0 = .cnoC .tsE
Figure 4B: Assay of whole blood extract (#473) targeting amphetamine
and its metabolites. The concentrations of ephedrine, benzoylecgonine
and cocaine are estimated because labeled internal standards were not
added to sample extract.
Thermo Fisher Scientific,
San Jose, CA USA is ISO Certified.
For Research Use Only. Not for use in diagnostic procedures.
Legal Notices
©2007-2008 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. This infor-
mation is presented as an example of the capabilities of Thermo Fisher Scientific Inc. products. It is not intended to encourage use of these products in any
manners that might infringe the intellectual property rights of others. Specifications, terms and pricing are subject to change. Not all products are available in
all countries. Please consult your local sales representative for details.
In addition to these
offices, Thermo Fisher
Scientific maintains
a network of represen-
tative organizations
throughout the world.
Africa-Other
+27 11 570 1840
Australia
+61 2 8844 9500
Austria
+43 1 333 50 34 0
Belgium
+32 2 482 30 30
Canada
+1 800 530 8447
China
+86 10 8419 3588
Denmark
+45 70 23 62 60
Europe-Other
+43 1 333 50 34 0
Finland/Norway/
Sweden
+46 8 556 468 00
France
+33 1 60 92 48 00
Germany
+49 6103 408 1014
India
+91 22 6742 9434
Italy
+39 02 950 591
Japan
+81 45 453 9100
Latin America
+1 608 276 5659
Middle East
+43 1 333 50 34 0
Netherlands
+31 76 579 55 55
South Africa
+27 11 570 1840
Spain
+34 914 845 965
Switzerland
+41 61 716 77 00
UK
+44 1442 233555
USA
+1 800 532 4752
www.thermo.com