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Application Note 608
Conclusion
The quantification of a panel of antiepileptic drugs in
human plasma has been implemented and analytically
validated on a TSQ Quantum Access MAX mass
spectrometer using the MassTox TDM Series A kit for
antiepileptics from Chromsystems. The TSQ Quantum
Access MAX mass spectrometer proved to have the
proper sensitivity, accuracy, and precision for the
application of this analytical method to clinical research.
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Figure 3. Representative chromatograms of each analyte at the
LOQ and corresponding IS for Group 2
Figure 4. Representative chromatograms of each analyte at the
LOQ and corresponding IS for Group 3
1.0 1.5 2.0 2.5
Time (min)
0
20
40
60
80
100
0
20
40
60
80
100
0
20
40
60
80
100
0
20
40
60
80
100
RT: 1.32
RT: 1.35
RT: 1.32
RT: 1.32
1.0 1.5 2.0 2.5
Time (min)
0
20
40
60
80
100
0
20
40
60
80
100
0
20
40
60
80
100
Relative Abundance
0
20
40
60
80
100 RT: 1.15
RT: 1.34
RT: 1.44
RT: 1.84
IS5
IS13
IS5
IS5
PEMA
Primidone
Stiripentol
Phenytoin
0.5 1.0 1.5 2.0 2.5
Time (min)
0
20
40
60
80
100
0
20
40
60
80
100
Relative Abundance
0
20
40
60
80
100 RT: 1.24
RT: 1.43
RT: 1.75
1.50
1.88
2.13
0.5 1.0 1.5 2.0 2.5
Time (min)
0
20
40
60
80
100
0
20
40
60
80
100
0
20
40
60
80
100 RT: 1.24
1.43 1.50
0.87
RT: 1.43
RT: 1.75
IS18
IS16
IS17
Zonisamide
Phenobarbital
Valproic
Acid