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6.5

7.0

7.5

8.0

8.5

9.0

9.5

Time (min)

0

20

40

60

80

100

RelativeAbundance

0

RelativeAbundance

0

20

40

60

80

100

RelativeAbundance

JWH-073-OH

1

2

3

4

5

6

7

8

JWH-018-OH

JWH-073-COOH

JWH-018-COOH

Figure 3. SRM chromatogram of a 2 ng/mL standard showing resolution of analytes from unknown

endogenous interferences.

6.5

7.0

7.5

8.0

8.5

9.0

9.5

Time (min)

0

20

40

60

80

100

RelativeAbundance

0

20

40

60

80

100

RelativeAbundance

0

20

40

60

80

100

RelativeAbundance

JWH-073-OH

JWH-018-OH

JWH-073-COOH

JWH-018-COOH

Figure 4. SRM chromatogram of a 100 ng/mL standard.