BR21466-EN Liquid chromatography columns for every biopharma

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Sample Preparation
for
increased sensitivity
Sample Handling
The highest level of sample
integrity and sample
information possible
Column UHPLC
Built for every
biopharma workflow
Mass Spectrometry
Thermo Scientific™
The new standard in
characterization and quantitation
Antibody Drug Conjugates (ADCs) are a new
and exciting class of drugs designed for
the targeted treatment of certain cancers.
They consist of a monoclonal antibody with
a synthetic small molecule drug or drugs
joined (conjugated) to them. Combining
the capabilities of the monoclonal antibody
with a cancer-killing drug allows sensitive
discrimination between healthy and
diseased cells. Development of these
biotherapeutics is even harder than with
monoclonal antibodies due to the potency
of the attached drug, sometimes called the
“payload” or “warhead”. In addition to the
analysis carried out on standard antibodies,
further characterization is needed to
determine how much of the drug is attached
to the antibody. This is known as Drug to
Antibody Ratio (DAR).
Antibody Drug Conjugates
Recommended Column
Thermo Scientific ™
.6 × 100 mm column
Product code: 088558
• Antibody drug conjugates (ADC) require
extended characterization to determine the
amount of drug attached to monoclonal
antibody due to potency of attached drug
• Confirmation of Drug to Antibody Ratio (DAR)
for ADC
• Stable at wide pH range 2-12