Antibodies are becoming increasingly
important in the development and
manufacture of drugs globally. During the
manufacturing process, antibodies and
other proteins can form aggregates – these
occur when several structures join together
to form larger, higher order structures. This
can impact the efficacy of a drug, which
ultimately can lead to severe side-effects
for the consumer. Biopharmaceutical
companies therefore have a requirement
to accurately measure this aggregation to
ensure that levels are minimized.
Recommended Column
Thermo Scientific
™
MAbPac ™ SEC-1 5 µm,7.8 x 300 mm column
Product code: 088460
• Features a proprietary hydrophilic bonded
layer, designed to minimize the interactions
between the biomolecules of interest and
the stationary phase
• Provide accurate quantification of
aggregation level within the drug
• Confirmation of drug safety within
regulatory requirements
Aggregation
Sample Preparation
Thermo Scientific
™
SOLAµ ™ SPE Platesfor increased sensitivity
Sample Handling
Thermo Scientific
™ Virtuoso ™ VialsThe highest level of sample integrity
and sample information possible
Column
MAbPac SEC-1 BioLC ColumnsUHPLC
Thermo Scientific
™
Vanquish ™ UHPLC SystemsBuilt for every biopharma workflow