BR21466-EN Liquid chromatography columns for every biopharma

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During the biotherapeutic protein production
process, a large number of chemical and/
or structural changes can occur. Two of the
most common modifications are:
• Deamidation – damage of
amide-containing side chains of amino
acids such as asparagine and glutamine
• Methionine oxidation – which deactivates
some protein activities
These chemical changes can reduce or
even negate the effect of the protein. During
protein characterization, confirmation of
these modifications is required.
Chemical Modification
(deamidation and oxidation)
Recommended Column
Thermo Scientific ™
4.6 × 100 mm column
Product code: 088553
• Identification of unwanted chemical
modifications, resultant of the protein
production process; these modifications
can affect the efficacy of the biotherapeutic
protein
• Separation of mAb fragments from oxidized
and damaged compounds
Sample Preparation
for
increased sensitivity
Sample Handling
The highest level of sample
integrity and sample
information possible
Column UHPLC
Built for every
biopharma workflow
Mass Spectrometry
Quantify, confirm and characterize
compounds in a single analysis