Application Note 52279
As an additional test, the ion ratio at different levels has
been monitored and the deviation of the transitions has
been calculated.
Compound
Ion Ratio Deviation RSD in % (n=5)
Phosmet
0.79
Azinphosmethyl
3.65
Chlorfenapyr
15.08
Deltamethrin
0.88
Iprodion
5.34
Alfa Endosulfan
3.63
Methidathion
0.84
Carbaryl
3.64
Cyfluthrin
3.55
Pyrimifos
3.83
Table 3: Ion ratio deviation of some challenging pesticides in
cucumber matrix at several levels of concentration
Figure 3 (a) through (f) show a 1 ppb matrix spike and
calibration data obtained for select targeted pesticides in
cucumber matrix.
Conclusions
•
Advances in HyperQuad technology offers increased
analytical performance for routine applications such as
pesticide analysis.
•
A true multi-compound method was developed for over
400 pesticides using timed SRM; easily transferable
from a spreadsheet.
•
A high level of accuracy and precision was reached
during data evaluation, on several cornerstones of
analysis, such as repeatability, linearity and ion ratio
stability.
•
Furthermore, all examples shown are the more
challenging pesticides faced analytically in terms of
stability, activity and response.
•
This resolution technology development allows for
advanced GC-MS/MS operations to be performed,
such as U-SRM to further increase selectivity in
complex matrices. This not only improves quantitative
measurements, but it is also amenable when using a
reduced sample clean-up which is typical for QuEChERS
methodologies.
References
1. REGULATION (EC) No 396/2005 and amendments, Feb. 23 2005.
2. M. Anastassiades, S. Lehotay D. Steinbacher, F. Schenck,
J. AOAC
Int.
86 (2) (2003) 412.
3. Munari, F., Huebschmann, H.J., Eliminating High Boiling Matrix in
GC and GC/MS by Using PTV Backflush Injection Technique for
Increased Productivity and Reliability, Application Note 51888,
Thermo Fisher Scientific, 2010.
4. Pesticides Method Reference, 2nd ed. 2011, Thermo Fisher Scientific,
Austin, TX, USA, (part number 120390).
For reference on Thermo Scientific QuEChERS products, please see our catalog, Thermo
Scientific HyperSep Dispersive SPE Products (part number BRGSCQUECHERS 1109).
AN52279_E 08/12M
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