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286.9

287.0

287.1

287.2

287.3

m/z

0

5

10

15

20

25

30

35

40

45

50

55

60

65

70

75

80

85

90

95

100

Relative Abundance

287.22174

287.08087

287.20474

287.10028

287.23709

287.16766

287.05829

287.27325

286.95816

Oxazepam

Figure 3. SIM spectrum of oxazepam in urine at mass resolution of 140,000 FWHM

Figure 4 and Table 2 demonstrate the overall

quantitative performance of the Q Exactive mass

spectrometer for diazepam in urine. The calibration

curve for diazepam in Figure 4 shows a linear dynamic

range of over four decades (0.0125 – 250 ng/mL),

including the inset from 0.0125 to 0.25 ng/mL, with

Figure 4

Diazepam

Y = -600.05+932195*X R^2 = 0.9998 W: 1/X

0

50

100

150

200

250

ng/mL

20000000

40000000

60000000

80000000

100000000

120000000

140000000

160000000

180000000

200000000

220000000

240000000

260000000

Area

Diazepam

Y = -600.05+932195*X R^2 = 0.9998 W: 1/X

0.00 0.05 0.10 0.15 0.20 0.25 0.30

ng/mL

20000

60000

100000

140000

180000

220000

260000

300000

Area

Figure 4. Calibration curve for diazepam in urine from 0.0125 – 250 ng/mL