LC-MS Applications for Environmental Analysis

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PROPYLENE GLYCOL MONOMETHYL ETHER (PGME)
RT
Syringe
Speed Aver Height
Background
Subtracted
11.00 OFF 12500
7.30 68039 55539
Propylene Glycol Monomethyl Ether (PGME)
RT (min)
Syringe
Speed Average Height
Background
Subtracted
Response/ISTD
Ratio
Concentration
(µg/m3)
9.8 - 10.6 9 9237720 8943477 161.0 260
12.2 -13.0 7 4458866 4164623 75.0 104
14.8 - 15.6 5 2181745 1887502 34.0 52
17.1 - 17.9 3 1015925 721682 13.0 21
19.1 - 19.9 1 659715.5 365473 6.6 10
21.2 - 22.0 OFF 294243 0 0.0 0 Std. Dev. = 15262
(3 x Std. Dev.) = 45785 0.8 1 LOD
ISTD: Acetone d6 , syringe 1 mL, Speed 2
SRM (m/z 65 →m/z 33)
MRM (m/z 91→m/z 33 + m/z 91→m/z 73)
RT: 7.80 -22.30 SM: 7B
8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
RelativeAbundance
260ug/m3
Av.Ht.=9237720
104ug/m3
Av.Ht.=4458866
52ug/m3
Av.Ht.=2181745
21ug/m3
Av.Ht.=1015925
10ug/m3
Av.Ht.=659715
Background
Av.Ht.=294243
NL:9.84E6
TIC F:+cAPCI
sid=5.00 SRMms2
21.00
[30.500-31.500;
72.500-73.500] MS
PGMEcourb
Calibration Curve
PROPYLENE GLYCOL MONOMETHYL ETHER
y = 0.0018x 2 + 1.3112x
R 2 = 0.9986
0
50
100
150
200
250
300
0 20 40 60 80 100 120 140 160 180
Conc. ug/m 3
Ratio (m/z 91 →m/z 31 +m/z 91 →m/z73)/ISTD
Figure 8: Calibration curve for PGME.
Figure 7: Reconstructed ion trace for PGME to produce the calibration curve.
Table 7. Quantitative results for PGME, and LOD determination.