115 / 302
4.5
5.0
5.5
6.0
6.5
7.0
Time (min)
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
RT: 6.29
AA: 5797
RT: 6.43
AA: 8520
RT: 6.55
AA: 8058
RT: 6.25
AA: 2716
RT: 6.61
AA: 22391
RT: 6.59
AA: 18998
RT: 6.79
AA: 7998
RT: 6.81
AA: 25414
RT: 6.02
AA: 1639
6.0
6.5
7.0
7.5
8.0
8.5
Time (min)
RT: 7.70
AA: 7901
RT: 7.74
AA: 8205
RT: 7.81
AA: 8448
RT: 8.10
AA: 13156
RT: 8.22
AA: 42335
RT: 8.39
AA: 8141
RT: 8.43
AA: 4026
5
6
7
8
Time (min)
RT: 6.98
AA: 31162
RT: 7.02
AA: 18888
RT: 7.08
AA: 4554
RT: 7.14
AA: 5093
RT: 7.25
AA: 6110
RT: 7.33
AA: 15417
RT: 7.63
AA: 44411
Ciprofloxacin
(1 ng/L)
Lomefloxacin
(1 ng/L)
Tetracycline
(10 ng/L)
Sulfamethazine
(10 ng/L)
Enrofloxacin
(1 ng/L)
epi-Chlorotetracycline
(100 ng/L)
Sulfamethazole
(10 ng/L)
Metoprolol
(10 ng/L)
Demeclocycline
(100 ng/L)
Sarafloxacin
(1 ng/L)
Penicillin G
(100 ng/L)
Digoxigenin
(10 ng/L)
Cocaine
(1 ng/L)
Azithromycin
(10 ng/L)
Sulfachloropyridazine
(10 ng/L)
Penicillin V
(100 ng/L)
Doxycycline
(10 ng/L)
Sulfamethoxazole
(10 ng/L)
Cocaethylene
(1 ng/L)
Digoxin
(100 ng/L)
Propranolol
(1 ng/L)
Figure 7. Example chromatograms of the PPCPs in water at the ng/L level. The LLOQ for each compound is listed in parentheses. (continued)
8
9
10
Time (min)
RT: 9.32
AA: 10169
RT: 9.45
AA: 7681
RT: 9.46
AA: 58538
RT: 9.50
AA: 5640
RT: 9.57
AA: 19522
RT: 9.79
AA: 1628
RT: 10.29
AA: 9502
7.0
7.5
8.0
8.5
9.0
9.5
Time (min)
RT: 8.76
AA: 11698
RT: 8.83
AA: 57545
RT: 9.01
AA: 9582
RT: 9.12
AA: 9402
RT: 9.15
AA: 74405
RT: 9.27
AA: 19291
RT: 9.33
AA: 3972
6.5
7.0
7.5
8.0
8.5
9.0
Time (min)
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
0
50
100
RT: 8.49
AA: 23044
RT: 8.56
AA: 12492
RT: 8.56
AA: 22100
RT: 8.61
AA: 6460
RT: 8.69
AA: 5490
RT: 8.71
AA: 24841
RT: 8.74
AA: 28204
Dextromethorphan
(1 ng/L)
Erythromycin
(10 ng/L)
Midazolam
(1 ng/L)
1-OH Midazolam
(1 ng/L)
Anhydrotetracycline
(10 ng/L)
Diphenhydramine
(1 ng/L)
Tylosin
(10 ng/L)
Sulfadimethoxine
(1 ng/L)
Diltiazem
(1 ng/L)
Anhydroerythromycin
(1 ng/L)
1-OH Alprazolam
(10 ng/L)
Carbamazepine
(1 ng/L)
Roxithromycin
(1 ng/L)
Clarithromycin
(1 ng/L)
Oxacillin
(100 ng/L)
Alprazolam
(1 ng/L)
Flumequine
(1 ng/L)
Fluoxetine
(1 ng/L)
Cloxacillin
(100 ng/L)
Miconazole
(1 ng/L)
Nordiazepam
(1 ng/L)
Figure 7. Example chromatograms of the PPCPs in water at the ng/L level. The LLOQ for each compound is listed in parentheses. (continued)
c
b