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4.0

5.0

6.0

0

10

20

30

40

50

60

70

80

90

100

Relative Abundance

Retention Time (min)

7-Aminonitrazepam

7-Amino-

clonazepam

7-Aminoflunitrazepam

Diazepam

Midazolam

Alprazolam

Nordiazepam

Temazepam

Desalkylflurazepam

2-Hydroxyethylflurazepam

_

-Hydroxyalprazolam

_

-Hydroxytriazolam

Oxazepam

Lorazepam

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Conclusion

We have developed a fast and sensitive LC-MS method

for 14 benzodiazepines in urine using a benchtop Exactive

mass spectrometer with TraceFinder 1.1 software.

TraceFinder 1.1 software is easy to use and effective in

performing quick routine quantitative analysis of benzo-

diazepines in urine. The software enables easy method

development, batch creation, submission and real time

monitoring for clinical research laboratories. The data

review functionality was very useful in quick review

and verification of the calibration accuracy and linearity.

The report templates make selecting and generating reports

with all the necessary information easy and quick.

For Research Use Only. Not for use in diagnostic procedures.

Figure 10. Extracted ion chromatograms of 14 benzodiazepines in urine at their LLOQ (5 ng/mL, mass isolation window=3 ppm)