76 / 302
Conclusion
The advantage of the IC-MS/MS methodology described
here is the elimination of derivatization and acidification
steps required by EPA Method 547 and other techniques.
The analysis requires no sample preparation. Separation
of both compounds in both dimensions occurs in
approximately 30 minutes. Calibration levels of 0.05 to
50 ppb for glyphosate show that this method can be used
to quantitate low (ppb) levels of glyphosate in high-ionic
strength matrices. Using stable-labeled internal standards
will help compensate for the effects of ion suppression in
the source.
References
1. Tu, M.; Hurd, C.; and Randall, J.M. Weed Control Methods Handbook,
The Nature Conservancy,
http://tncinvasives.ucdavis.edu,Version: April
2001
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2. United States Geological Survey, “Glyphosate Found in Wastewater
Discharged to Streams,”
http://toxics.usgs.gov/highlights/glyphosate_wastewater.html(Accessed
January 7,
2009
).
3. Kolpin, D.W.; Thurman, E.M.; Lee, E.A.; Meyer, M.T.; Furlong, E.T.; and
Glassmeyer, S.T. “Urban contributions of glyphosate and its degradate
AMPA to streams in the United States”; Science of the Total Environment,
2006
, 354 (2-3), 191-197. doi: 10.1016/j.scitotenv.2005.01.028
4. Beyond Pesticides, “Denmark Restricts Water-Contaminating Herbicide,”
http://www.beyondpesticides.org/news/daily_news_archive/2003/9_23_03.htm (Accessed January 8, 2009).
5. Richard, S.; Moslemi, S.; Sipahutar, H.; Benachour, N.; and Seralini, G-E
“Differential effects of glyphosate and Roundup on human placental cells
and aromatase”; Environmental Health Perspectives,
2005
, 113(6) 716-
720. doi:10.1289/ehp.7728
6. Unites States Environmental Protection Agency, “Consumer Factsheet on
Glyphosate,”
http://www.epa.gov/OGWDW/contaminants/dw_contamfs/glyphosa.html(Accessed January 5, 2008).
7. Unites States Environmental Protection Agency, “Method 547:
Determination of glyphosate in drinking water by direct-aqueous-injection
HPLC, post-column derivatization, and fluorescence detection,”
http://www.accustandard.com/asi/pdfs/epa_methods/547.pdf(Accessed
January 5, 2008).
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