LC-MS Applications for Environmental Analysis

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Conclusion
Using a preconcentration column in tandem with an
analytical HPLC column allowed for the quantitation of
a triazine herbicide mixture over the concentration range
0.1 – 10.0 pg/mL. Direct 20 mL injections were performed
with the two HPLC columns. The large injection volume
capabilities of the EQuan system eliminated the need for
laborious and expensive offline preconcentration using
solid phase extraction. Injection volumes ranging from
1 mL to 20 mL are possible using this configuration, thus
offering flexibility for laboratories based on their
sensitivity and reporting requirements.
Acknowledgements
We would like to thank Scott Harrison from LEAP
Technologies (Carrboro, NC) for assistance with the CTC
macro for multiple syringe fills and Mark Harrison from
Thermo Fisher Scientific (Hemel-Hempsted, UK) for further
assistance with the macro and for technical discussions.
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Figure 4. QED-MS/MS Q3 spectrum for a 1pg/mL injection of atrazine. The collision energy was 25 eV and the ramp was 20 eV.