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View additional Thermo Scientific LC/MS application notes at:
www.thermo.com/appnotesConclusion
IC-MS/MS is a powerful tool used in the quantitation of
haloacetic acid samples. When compared to the
conventional EPA methods using GC with electron
capture, using IC-MS/MS to analyze for haloacetic acids
saves analysts several hours of sample preparation
because there is no requirement for sample pre-
treatment. The resolution between the matrix peaks and
haloacetic acids is excellent, which allows for minimum
interference in detection.
Excellent recoveries and reproducibility were
achieved when samples were spiked into a simulated
matrix containing 250 mg/L of each of chloride and
sulfate, 150 mg/L bicarbonate, 30 mg/L of nitrate and
100 mg/L ammonium chloride preservative for a total
chloride concentration of 316 mg/L. Results are
comparable to those achieved in EPA Method 552.2.
Analyte
Average RT
%RSD RT Average Area %RSD Area
MCAA
12.59
0.00
764439
2.34
MBAA
14.06
0.27
1627886
2.91
DCAA
24.44
0.02
11236488
3.98
BCAA
26.88
0.18
2468467
4.85
DBAA
30.09
0.16
731710
3.26
TCAA
39.05
0.24
4855405
10.98
BDCAA
45.13
0.04
1212887
4.78
DBCAA
43.55
0.07
1064
22.20
TBAA
47.44
0.25
1333
17.60
Calculated EPA Method
Analyte
MDL (µL/L)
552.2 MDL (µL/L)
MCAA
0.203
0.273
MBAA
0.392
0.204
DCAA
0.097
0.242
BCAA
0.136
0.251
DBAA
0.100
0.066
TCAA
0.403
0.079
BDCAA
0.159
0.091
DBCAA
0.459
0.468
TBAA
0.407
0.820
References
1. U.S. Environmental Protection Agency,
Microbial Health Effects Tables:
Potential Adverse Health Effects from High/Long-term Exposure to
Hazardous Chemicals in Drinking Water,
2002.
2. U.S. Environmental Protection Agency, Method 552.1,
Determination of
Haloacetic Acids and Dalapon in Drinking Water by Ion Exchange
Liquid-Solid Extraction and Gas Chromatography with Electron
Capture Detection,
Rev. 1.0, 1992.
3. U.S. Environmental Protection Agency, Method 552.2,
Determination of
Haloacetic Acids and Dalapon in Drinking Water by Liquid-Liquid
Extraction, Derivatization, and Gas Chromatography with Electron
Capture Detection,
Rev 1.0, 1995.
4. U.S. Environmental Protection Agency, Method 552.3,
Determination of
Haloacetic Acids and Dalapon in Drinking Water Liquid-Liquid
Microextraction, Derivatization, and Gas Chromatography with
Electron Capture Detection,
Rev 1.0, 2003.
5. Slignsby, R.; Saini, C.; Pohl, C.; Jack, R.
The Measurement of Haloacetic
Acids in Drinking Water Using IC-MS/MS–Method Performance,
Presented at the Pittsburgh Conference, New Orleans, LA, March 2008.
Table 5. Reproducibility of area and retention time in the TSQ Quantum Access for seven injections
of 2 ppb concentration in simulated matrix
Table 6. Calculated MDL response of HAA9 on the TSQ Quantum Access