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Figure 5: Linearity of the UHPLC/MS method for the analyses of explosives compounds in soil matrices
Conclusions
The simultaneous analyses of nitroamines, nitroaromatics,
nitrate esters, and peroxide explosives by UHPLC/MS were
accomplished. The UHPLC method, utilizing sub-2 µm
particles, improved the separation efficiencies and resolutions.
The MS detection method offered improved sensitivities,
good selectivity and additional MS confirmations. The
detection sensitivities were further increased by the pre-
concentration step implemented in the sample preparation
process. The more confirmative identifications of explosives
were achieved by comparing of the collected APCI mass
spectra to the comprehensive MS spectra library of the
explosive residues. We demonstrated the improved
separation performance, increased detection sensitivity
and better selectivity, compared to the current USEPA
8330 method. We also achieved 35 times detection
sensitivity for TATP compared to the Agilent instrument
and method.
References
1. D.R. Felt, S.L. Larson and L.Escalon, An extraction/concentration procedure
for analysis of low-level explosives in soils; Talanta 76, (2008) 21-28.
2. R. Tachon, V. pichon, M. B. Le Borgne, J-J. Minet, J. Chromatogr. A
(2007), doi : 10.1016/j.chroma.2007.03.059
3. Agilent Application : Analysis of Trace Residues of Explosive Materials by
Time-of-Flight LC/MS
4. A. Gapeev, M. Sigman and J. Yinon, Liquid chromatography/mass
spectrometric analysis of explosives: RDX adduct ions; Rapid Commun.
Mass Spectrum. 2003;17:943-948