LC-MS Applications for Environmental Analysis

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AN63413_E 06/11S
Conclusion
In this screening and quantitation method to indentify
pesticides in water, the combination of two different
extraction columns yielded easy access to a wide range
of environmental compounds in one general approach.
ExactFinder software provided a single streamlined
workflow with high productivity and confidence required
for targeted and non-targeted screening experiments.
Full qualitative data was attained from the same data set
in one workflow, and a wide range of confirmation tools
for known analytes were available. An additional search
led to the identification of a number of non-targeted
analytes and yielded a large number of compounds, to
which elemental compositions can be assigned in most
cases. Lastly, acquiring the data at 50,000 resolution
reduces the likelihood of coeluting isobaric interferences
and thus diminishes the likelihood of false positives.
References
1. Zhang, A., Chang, J., Gu, C., Sanders, M. Non-targeted Screening and
Accurate Mass Confirmation of 510 Pesticides on the High Resolution
Exactive Benchtop LC/MS Orbitrap Mass Spectrometer, Thermo Fisher
Scientific Application Note 51878, 2010.
2. Beck, J., Yang, C. LC-MS/MS Analysis of Herbicides in Drinking Water
at Femtogram Levels Using 20 mL EQuan Direct Injection Techniques,
Thermo Fisher Scientific Application Note 437, 2008.
Figure 4. Isotopic pattern matching example
Red line: Theoretical profile Green line: Experimental profile
Figure 4. Isotopic pattern matching example