Page 64 - CRFTApplication Compendium_090613
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Conclusion
A fast, sensitive and reliable LC-MS/MS SRM method has
been developed for the determination of testosterone in
serum. Sample analysis was performed with a run time
of 7 minutes with a quantitation limit of 11 ng/dL and
a linearity range of 11-2000 ng/dL. The low intra-assay
and inter-assay variability of the results demonstrates the
reliability of the method for research laboratories.
References and Acknowledgement
Sizonenko PC, Paunier L: Hormonal changes in puberty III: Correlation of
plasma dehydroepiandrosterone, testosterone, FSH and LH with stages of
puberty and bone age in normal boys and girls and in patients with
Addison’s disease or hypogonadism or with premature or late adrenarche.
Journal of Clinical Endocrinology & Metabolism. 41:894, 1975.
New MI, Josso N: Disorders of gonadal differentiation and congenital
adrenal hyperplasia.
Endocrinology & Metabolism Clinics of North America
1988; 17:339-366.
Goudas VT, Dumesic DA: Polycystic Ovary Syndrome.
Endocrinology &
Metabolism Clinics of North America 1997; 26:893-912.
Braunstein GD. Androgen insufficiency in women: summary of critical issues.
Fertility & Sterility. 77 Suppl 4:S94-9, 2002.
Juul A, Skakkebaek NE: Androgens and the ageing male.
Human
Reproduction Update 2002; 8: 423-33.
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