November 2012

In Issue 63

Tip of the month

How to overcome limitations of peptide-centric proteomics and cover a large number of functional pathways

 

Using Thermo Scientific™ ProteinCenter software, scientists confidently interpret complex data sets and extract meaningful biological information within minutes of an analysis that could take months to finalize using conventional bioinformatics software tools.

PlanetOrbitrap: unprecedented access to scientific, product, and community content

 

This enhanced website offers both current and prospective customers in-depth access to rich content on the Thermo Scientific Orbitrap™ technology platform. It includes comprehensive workflows from sample preparation to data analysis, a curated library of 1,000+ scientific resources, multiple tools for optimizing system performance, details on the Orbitrap family of mass spectrometry instruments, a new global events listing, and community features such as a job board, user profiles, and sharing tools.

1.39MB

Application Note: Relative Quantitation of TMT-Labeled Proteomes - Focus on Sensitivity and Precision

 

In this note we evaluated the impact of the technological advances of hybrid instruments on overall experimental outcome in terms of protein/peptide identification and quantitation. The focus was on assessing the percentage of quantifiable peptides, the quantitative precision, and the quantitative accuracy.

Free Glycan Analysis Reference Card!

 

Add it to your employee badge holder and have quick reference to the Domon and Costello Nomenclature as well as mass values of some of the most common monosaccharides and substituents.

19:51min

Video: Metabolomic Profiling in Drug Discovery: Understanding the Factors that Influence a Metabolomics Study and Strategies to Reduce Biochemical and Chemical Noise

 

In this video, new mass spectrometer technology and data processing software is shown to utilize the reduction of chemical noise. Experiments are discussed to understand the influence of animal age and nutrition in an attempt to contextualize drug-induced changes in effect reducing the biochemical noise.

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Poster note ASMS 2012: Quantitative Bioanalysis using the
Q Exactive HRMS: Factors in choosing Resolution and Scan Type

 

This poster presentation from ASMS 2012 highlights the Thermo Scientific Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer, which is rapidly being adopted for quantitative bioanalysis of both large and small molecules. Using the Q Exactive HR/AM MS, it gives scientists flexibility with a broad range of quantitative capability that cannot be achieved by even the most sensitive triple quadrupoles for routine bioanalysis.

29:47min

Analysis of Synthetic Cannabinoids (Spice) in Urine
Utilizing HRAM

 

This talk presents a LC high-resolution, accurate-mass mass spectrometry approach to fast quantitative and qualitative analysis of Synthetic Cannabinoids (Spice) drugs and metabolites in urine. The benefits of this approach over MRM for the fast analysis of JWH (SPICE) metabolites are presented. The talk also discusses various hydrolysis approaches, presents comparative data, and pros and cons of each.

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Automated Online Multi-Residue LC-MS/MS Method for the Determination of Antibiotics in Chicken Meat

 

This note describes a multi-residue, confirmatory method for the quantitative determination of antibiotics in chicken meat using the Thermo Scientific Transcend™ TLX system coupled to an LC-MS/MS. The Transcend TLX system, powered by TurboFlow™ technology, was used for online sample cleanup instead of lengthy offline solid-phase extraction (SPE). Combining the number of target compounds with the high sample throughput, this approach fulfills the demand for a fast and cost-effective multi-analyte method.

Seminar

Nov. 7 − 17
2012

Full-Day (Free) Proteomics & Metabolomics Seminar
for LC-MS

 

Ignite your workflows with our cutting-edge LC-MS technology. Application experts and local guest speakers will be presenting on variety of topics including: Discovery Proteomics; Glycoproteomics & Glycomics; Discovery Metabolomics; Targeted Protein Quantification using HR/AM; Targeted Qualitative & Quantitative Studies; and more!

Trade Show

Nov. 11 − 15
2012

Catch the Next Wave with Thermo Fisher Scientific
at SETAC 2012

 

Long Beach, California. Stop by booth #219 to learn more about how you can advance with our total workflow solutions that cover identification, quantification, and confirmation. Topics highlighted include:

Trade Show

May 20 − 24
2012

ASMS 2012, May 20 − 24, 2012 | Vancouver, BC, Canada

 

All Thermo Scientific Technical posters presented at ASMS 2012 are now available for download at:

We hope to see you at next year's 61st ASMS Conference, June 9 − 13, 2013 in Minneapolis, Minnesota

Trade Show

Sept. 9 − 13
2012

HUPO 2012, September 9 − 13, 2012 | Boston MA

 

All Thermo Scientific Technical posters presented at HUPO 2012 are now available for download at:

We hope to meet you next year for the HUPO 12th Annual World Congress, September 14 − 18, 2013 in Yokohama, Japan

Now accepting the trade-in of triple quadrupole and ion trap mass spectrometers from all manufacturers

 

Upgrade the analytical power of your laboratory by trading in any existing triple stage quadrupole mass spectrometer or ion trap mass spectrometer from any manufacturer for a discount on one of our industry-leading Thermo Scientific triple stage quadrupole LC/MS systems or Thermo Scientific ion trap LC/MS systems.

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