Tip of the Month
Chromatography
& Mass Spectrometry Product Reference Guide
 With the recent
expansion of our product portfolio, along with the addition of the Dionex
family of products, we are pleased to share a handy resource which
provides a comprehensive snapshot of the solutions we now offer. Download
the new Chromatography
& Mass Spectrometry Product Reference Guide [PDF 2.9 MB] to learn
more about our expanded portfolio today!
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Highlights from ASMS 2011 in Denver, Colorado
 Take a virtual
tour of one of the most exciting ASMS conferences to date. From the
launch of innovative hardware platforms, including the ground-breaking
Thermo Scientific Q
Exactive, Orbitrap
Elite, Orbitrap
Velos Pro, Velos
Pro, and TSQ
Quantum XLS Ultra mass spectrometers to the expanded portfolio
offered by the recent Dionex acquisition, this tradeshow offered lots of
exciting new solutions for our valued customers.
View the Video: Highlights
from ASMS 2011 [2.50 min.]
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Thermo Scientific Orbitrap Elite Hybrid MS
High-Field
Orbitrap™ creates new possibilities in research and discovery
 The Orbitrap
Elite™ integrates a novel high-field Orbitrap with next-generation
dual-pressure ion trap technology to deliver unsurpassed resolving power,
increased sensitivity, high scan speeds and a larger dynamic range.
» Request More
Information
»
Download the Featured Poster: Orbitrap
Mass Spectrometry with Resolving Powers above 500,000 and 1,000,000 on
Chromatographic Time Scale [PDF 327 kB]
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Get a Personal
Glimpse at the New Orbitrap Elite Hybrid Mass Spectrometer
 Thomas Moehring and his team at Thermo
Fisher Scientific are proud to introduce this new high-field Orbitrap
hybrid MS. In this video, Dr. Moehring shows how this exciting innovation
delivers unsurpassed resolution for comprehensive qual/quan experiments
in the areas of proteomics, metabolomics, metabolism, and lipidomics.
With resolving power greater than 240,000 FWHM, this breakthrough
provides certainty in analytical results by enabling molecular weight
determination for intact proteins and in-depth analysis of isobaric
species.
»
View the Video: New
High-field Orbitrap Mass Spec: Ultimate Versatility and Performance
Introduced at ASMS [3.15 min.]
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Proteomics
Easy
Nano-UHPLC for Proteomics Research
 Operating at 1000 bar pressure, the Thermo
Scientific EASY-nLC 1000 nano-LC facilitates dedicated separation of
biomolecules, such as proteins and peptides, at ultra-high pressures.
Join Michael Andersen as he describes how this exciting new instrument is
extremely easy to use and seamlessly integrates with Thermo Scientific
mass spectrometers. Watch this video to learn about the benefits of
ultra-high pressure nano-flow LC.
» View
the Video: Easy
Nano-UHPLC for Proteomics Research [2.46 min.]
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New
Thermo Scientific Pierce MS Calibrations Solutions
 The new
Pierce® MS Calibration Solutions are ready-to-use liquid formulations
that consist of highly purified ionizable molecules that produce strong
peaks. Four reagents are available, designed for specific use with Thermo
Scientific LTQ
series, Orbitrap
series, LTQ Velos™ series, ion trap and triple quadrupole mass
spectrometers.
» Learn
More about the Pierce MS Calibrations Solutions
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New
Thermo Scientific Pierce Peptide Retention Time Calibration Solution
 The ready-to-use Pierce
Peptide Retention Time Calibration Mixture can be used to predict
peptide retention times on reversed-phase HPLC columns. It also
streamlines the transition from qualitative protein discovery results to
the development of targeted MS assays on Thermo Scientific triple
quadrupole, Orbitrap and Exactive Instruments and all other mass
spectrometers.
»
Learn More about the Pierce Peptide Retention Time Calibration Solution
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Metabolomics
Towards
a Universal LC/MS Method for Metabolomics
 Mass spectrometry lends itself to be an
excellent tool for both metabolomics discovery and screening, due to the
vast number of endogenous metabolites covering a wide range of analyte
concentrations. The large number of compounds also presents a unique challenge
for both the chromatography and mass spectrometry due to the wide range
of physical chemical properties. This poster, highlighting the
capabilities of the Thermo
Scientific Exactive benchtop Orbitrap, features the development of a
universal chromatographic method for LC-MS analysis.
»
Download the Featured Poster: Towards
a Universal LC/MS Method for Metabolomics [PDF 239 kB]
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Clinical Research and Forensic Toxicology
Four
Clicks to Quantitative Results
 Join Subodh Nimkar as he describes how Thermo
Scientific TraceFinder software is ideal for clinical research,
forensic toxicology, food safety and environmental testing laboratories
performing routine, high-throughput quantitation by LC-MS. Offering
complete integration with the Thermo
Scientific Transcend multiplexing system, TraceFinder™ software is a
single-software solution for method development, data acquisition, data
processing and reporting for use with Thermo Scientific TSQ
Series triple stage quadrupole LC-MS, the Exactive
benchtop LC-MS, the Orbitrap
Series high-resolution LC/MS, and the LTQ™
Series ion trap LC-MS.
» View the
Video: Four Clicks
to Quantitative Results [2.33 min.]
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Food Safety
A
Turn-key System for Automated Detection of Organic Contaminants in Food
Matrices and Economic Adulteration
 The future trend in food safety
analysis and in the detection of economically adulterated foods is the
implementation of "non-target" or full scan mass spectrometry
utilizing both high mass resolution and high accuracy. This poster
demonstrates the development and validation of a turn-key system for
automated detection of organic contaminants in food matrices and economic
adulteration. The benchtop Exactive
mass spectrometer system was used at 50,000 resolution (FWHM at m/z 200)
coupled with the Thermo
Scientific Accela ultra-high-pressure liquid chromatography (UHPLC).
» Download
the Poster: A
Turn-key System for Automated Detection of Organic Contaminants in Food
Matrices and Economic Adulteration
[PDF 805 kB]
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MALDI Solutions
On-Demand
Webinar: MALDI MS and MALDI MS Imaging with High Resolution/Accurate Mass
Performance Powered by Orbitrap Technology
 Join Dr. Kerstin Strupat in this
recorded webinar as she provides an in-detail view of the capabilities of
MALDI
technique in accordance with the high resolution Orbitrap mass analyzer.
»
Register to View the Webinar: MALDI
MS and MALDI MS Imaging with High Resolution/Accurate Mass Performance
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Biological
Applications of AP MALDI with Thermo Scientific Exactive Orbitrap MS
 The use of an AP MALDI ion source,
coupled to the Exactive
mass spectrometer, enables fast and sensitive analysis of a proteolytic
digest of a protein, mixtures of small molecules, N- and C-terminal
sequences of intact proteins via MALDI In Source Decay, and
straightforward exchange with ion sources, such as HESI
or APCI
on a daily basis.
»
Download the Application: Biological
Applications of AP MALDI with Thermo Scientific Exactive Orbitrap MS
[PDF 2.63 MB]
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Chromatography
Application
Notes Featuring Thermo Scientific Accucore HPLC Columns
Ultimate
Solid Core Performance to Maximize Your Investment
 A number of application notes are now available which feature the
use of the Core
Enhanced Technology™ Accucore™ HPLC columns. These illustrate the
high performance and speed of separation that can be achieved in a wide
range of application areas including: Environmental, Food,
Pharmaceutical, Bio-pharmaceutical, Clinical, Forensic and Forensic
Toxicology.
» For
more information visit www.thermoscientific.com/accucore
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New
Release: Thermo Scientific Hypersil GOLD Technical Guide Version 4.0
 This technical
guide has been updated to include information detailing the 12 different
chemistries in the expanded range of Hypersil GOLD™ columns, which now
offer chromatographers outstanding peak shape for reversed phase, ion
exchange, HILIC or normal phase chromatography. With all 12 phases
available with 1.9 um particle size, the expanded range of our Hypersil
GOLD columns delivers even more flexibility in choosing the correct
column, whether you're using conventional or ultra-high pressure LC
systems.
For
more information visit www.thermoscientific.com/hypersilgold
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Thermo
Scientific Hypercarb Columns Application Notebook
A
unique solution for difficult separations
 The Hypercarb™
Columns Application Notebook features applications for the
Biochemical, Food Safety, Environmental, Clinical, Food and Beverage
markets. It includes an application reference guide by solute type,
references and ordering information. The application notebook is now
available as:
» View the Interactive Online
Version
» View the Apple® iPad®-Optimized
Version
For
more information visit www.thermoscientific.com/hypercarb
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Trap Talk
Freedom
of Dissociation
 The Velos
Pro Ion Trap LC/MSn is the pinnacle of ion trap mass
spectrometry that delivers enhanced performance for the most complex
sample analyses. For the first time ever on an ion trap, the Velos Pro
ion trap LC/MSn offers Trap-HCD
(Higher-Energy Collisional Dissociation) combined with CID, PQD
and ETD
to solve the most difficult analytical problems. With the improved
robustness of generation II ion optics, the Velos Pro delivers
reliability on the fastest, most-sensitive, highest capability ion trap
available today.
» Request More Information &
Method-based Application Notes
»
Download the Featured Application: Quantitation
of Metabolites in Plasma Samples by UV-MS Correction using a
Dual-Cell-Linear Ion Trap Mass Spectrometer [PDF 400 kB]
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Explore
Thermo
Scientific Mass Spectrometry
Featured Thermo
Scientific News
Knowledge
Base for Chromatography & Mass Spectrometry
Upcoming
Thermo Scientific Worldwide Events
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Additional Information
Find
back issues of Critical Mass on the web at:
www.thermoscientific.com/criticalmass
Send
comments and suggestions to: criticalmass@thermofisher.com
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